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KMID : 0356919940270111646
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Korean Journal of Anesthesiology
1994 Volume.27 No. 11 p.1646 ~ p.1659
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The Effects of 10% Pentastrach Preloading for Cesarean Section Under Epidural Anesthesia
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Abstract
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Epidural anesthesia is the most commonly used anesthesia for cesarean section are particularly prone to arterial hypotension following sympathetic blockade. Its prevention is the most important thing to obstetric anesthetists. Forty women at term
were
randomly allocated to receive either
1,500ml of crystalloid (Hartmann's solution) or 500ml of colloid solution (10% pentastarch) in order to preload the circulation prior to elective cesarean section under epidural anesthesia. And to investigate the adverse effect of pentastarch on
coagulation, other forty mothers undergoing cesarean section under general anesthesia were examined with computerized thrombelastograph coagulation analyzer (TEG) before and after 1,500ml of Hartmann's solution or 500ml of 10% pentastarch
preloading
(each group n=20). There were no differences in the incidence of hypotension, degree of hemodilution, umbilical cord blood gas tension and TEG findings between the tow groups. But the serial change of the central venous pressure of the Hartmann
group
from fluid preloading to anesthesia and operation was significantly different from that of pentastarch group (p<0.05). The TEG findings before fluid preloading presented the hypercoagulable state of the pregnant women at term, and no adverse
effect
of
pentastarch on coagulation except hemodilution.
It was concluded that 10% pentastarch was a good choice as a circulatory preloading agent for cesarean section under epidural anesthesia.
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